Kern K., Delaroque N., Boysen A., Puder M., Wendt R., Kölsch A., Ehrentreich-Förster E.,Stærk K., Andersen TE., Andersen K., Lund L., Szardenings M.
Glycosylation of bacterial antigens changes epitope patterns.
Front. Immunol., 2023, 14:1258136. doi:10.3389/fimmu.2023.1258136
The differential influence of bacterial glycosylation on the immune response to a potential vaccine in animals was compared with the antibody response in infected patients. The use of epitopes, mimotopes, and mimotopes of glycosylation sites indicates the relevance of proper vaccine design.
Szardenings M., Delaroque N., Kern K., Ramirez-Caballero L., Puder M.,Ehrentreich-Förster E., Beige J., Zürner S., Popp G., Wolf J., Borte S.
Detection of Antibodies against Endemic and SARS-CoV-2 Coronaviruses with Short Peptide Epitopes.
Vaccines 2023, 11, 1403. doi: 10.3390/vaccines11091403
Coverage of the most common epitopes of Coronavirus-proteins revealed already at the start of the study in 2020 a close relationship in the immune response against endemic viruses and SARS-CoV-2, the initial article was rejected in 2021, “because it is not possible to do” what we have done.
Caballero LR, Treudler R, Delaroque N, Simon JC, Kern K, Szardenings M.
Peptide epitopes as biomarkers of soya sensitization in rBet v 1 immunotherapy of birch-related soya allergy.
Clin Exp Allergy. 2022 Sep 14. doi: 10.1111/cea.14224. Epub ahead of print. PMID: 36102274
IgG can do it as well. Not only IgE but also IgG epitopes can be biomarkers in allergy, too.
de Maat S, Clark C, Barendrecht AD, Smits S, van Kleef ND, El Otmani H, Waning M, van Moorsel MVA, Szardenings M, Delaroque N, Vercruysse K, Urbanus RT, Sebastian S, Lenting PJ, Hagemeyer CE, Renné T, Vanhoorelbeke K, Tersteeg C, Maas C.
Microlyse; a thrombolytic agent that targets VWF for clearance of microvascular thrombosis.
Blood. 2021 Nov 9:blood.2021011776. doi: 10.1182/blood.2021011776. Epub ahead of print. PMID: 34752601.
Ramírez Caballero L, Kny C, Treudler R, Simon JC, Kern K, Jappe U, Szardenings M.
Identification of Seasonal Variations of Antibodies against PR-10-Specific Epitopes Can Be Improved Using Peptide-Phage Display.
Int Arch Allergy Immunol. 2020 Aug 26:1-7. doi: 10.1159/000509995. Epub ahead of print. PMID: 32846424.
Even from sera: Sufficient data enable a statistical analysis of the seasonal changes in epitope preferences in differently sensitized patients.
Treudler R, Delaroque N, Puder M, Simon JC, Szardenings M.
Dupilumab-induced Serum Sickness Like Reaction: An Unusual Adverse Effect in a patient with atopic eczema.
J Eur Acad Dermatol Venereol. 2020 Jun 27. doi: 10.1111/jdv.16782. Online ahead of print. PMID: 32594596
Acute Allergy: From serum sample to the actual epitope in less than three weeks! Thanks to faster evaluation tools, epitope mapping of the antibodies and epitopes involved in allergic reactions could be identified quickly..
Kern K, Havenith H, Delaroque N, Rautenberger P, Lehmann J, Fischer M, Spiegel H, Schillberg S, Ehrentreich-Foerster E, Aurich S, Treudler R, Szardenings M.
The immunome of soybean allergy: Comprehensive identification and characterization of epitopes.
Clin Exp Allergy. 2019 Feb;49(2):239-251. doi: 10.1111/cea.13285. Epub 2018 Dec 3. PMID: 30267550.
Karolin Kern’s almost full mapping of the immune response against soy allergens in sensitized patients unravels a universe of epitopes with huge differences between individuals, and only a few of them seem to be relevant.
Havenith H, Kern K, Rautenberger P, Spiegel H, Szardenings M, Ueberham E, Lehmann J, Buntru M, Vogel S, Treudler R, Fischer R, Schillberg S.
Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants.
Biotechnol J. 2017 Feb;12(2). doi: 10.1002/biot.201600441.
Comparison of traditional peptide arrays and epitope fingerprinting with sera revealed insights into the structural function of an important food allergen.
Kunath J, Delaroque N, Szardenings M, Neundorf I, Straub RH.
Sympathetic nerve repulsion inhibited by designer molecules in vitro and role in experimental arthritis.
Life Sci. 2017 Jan 1;168:47-53. doi: 10.1016/j.lfs.2016.11.009. Epub 2016 Nov 14.
Although this publication is from the days we started evaluating NGS data using Excel data sheets, it still revealed interesting receptor epitopes..